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pyrosequencing-based methylation analysis  (Pyrosequencing Inc)

 
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    Pyrosequencing Inc pyrosequencing-based methylation analysis
    Pyrosequencing Based Methylation Analysis, supplied by Pyrosequencing Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pyrosequencing-based methylation analysis/product/Pyrosequencing Inc
    Average 90 stars, based on 1 article reviews
    pyrosequencing-based methylation analysis - by Bioz Stars, 2026-04
    90/100 stars

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    Effects of PA on DNA <t> methylation </t> patterns in BC populations. Table summarising the study design and results of interest from all selected articles that evaluated the effects of PA on DNA <t> methylation </t> signatures in BC patients. DNA <t> methylation </t> results are presented using the gene codes of the genes associated and/or affected by the PA-induced <t> methylation </t> changes reported by the original authors.
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    Association between progression-free survival (PFS) and the MGMTp methylation score. The association of the MGMTp methylation score, based on the MGMT-STP27 procedure, with progression-free survival (PFS; interval from diagnosis) was evaluated by the hazard ratio (confidence interval at 95%) from the cox regression model. The forest plots in A and B correspond to the PFS reported for patients treated in EORTC-22033 with temozolomide (TMZ) or radiotherapy (RT), respectively. , The MGMT-STP27 score was significant in the TMZ treated patients, but not in the patients with RT. The forest plots in C and D visualize the outcome of the Montpellier patients treated with TMZ, with time to progression defined by the next treatment-free survival (NxtTrtFS), and PFS defined by RANO, respectively. The MGMT-STP27 score was significant in the Montpellier cohort when using NxtTrtFS as outcome measure, a trend was observed when using RANO criteria for PFS. * P <.05; ** P <.01.

    Journal: Neuro-Oncology Advances

    Article Title: Clinical value of the MGMT promoter methylation score in IDHmt low-grade glioma for predicting benefit from temozolomide treatment

    doi: 10.1093/noajnl/vdae224

    Figure Lengend Snippet: Association between progression-free survival (PFS) and the MGMTp methylation score. The association of the MGMTp methylation score, based on the MGMT-STP27 procedure, with progression-free survival (PFS; interval from diagnosis) was evaluated by the hazard ratio (confidence interval at 95%) from the cox regression model. The forest plots in A and B correspond to the PFS reported for patients treated in EORTC-22033 with temozolomide (TMZ) or radiotherapy (RT), respectively. , The MGMT-STP27 score was significant in the TMZ treated patients, but not in the patients with RT. The forest plots in C and D visualize the outcome of the Montpellier patients treated with TMZ, with time to progression defined by the next treatment-free survival (NxtTrtFS), and PFS defined by RANO, respectively. The MGMT-STP27 score was significant in the Montpellier cohort when using NxtTrtFS as outcome measure, a trend was observed when using RANO criteria for PFS. * P <.05; ** P <.01.

    Article Snippet: The association between the MGMT-STP27 score and NxtTrtFS was confirmed using a pyrosequencing-based MGMTp methylation score (MGMT-PYROscore) obtained for the same samples ( P = .002, ).

    Techniques: Methylation, Biomarker Discovery

    Effects of PA on DNA methylation patterns in BC populations. Table summarising the study design and results of interest from all selected articles that evaluated the effects of PA on DNA methylation signatures in BC patients. DNA methylation results are presented using the gene codes of the genes associated and/or affected by the PA-induced methylation changes reported by the original authors.

    Journal: Cancers

    Article Title: Impact of Physical Activity on DNA Methylation Signatures in Breast Cancer Patients: A Systematic Review with Bioinformatic Analysis

    doi: 10.3390/cancers16173067

    Figure Lengend Snippet: Effects of PA on DNA methylation patterns in BC populations. Table summarising the study design and results of interest from all selected articles that evaluated the effects of PA on DNA methylation signatures in BC patients. DNA methylation results are presented using the gene codes of the genes associated and/or affected by the PA-induced methylation changes reported by the original authors.

    Article Snippet: The authors also analysed global DNA methylation in white blood cell DNA [ , ] using the luminometric methylation assay (LUMA), a quantitative measurement of genome-wide DNA methylation, as described by Bjornsson et al. [ ], and LINE-1, where four CpG sites in the promoter region of LINE-1 were assessed using a validated pyrosequencing-based methylation assay [ ].

    Techniques: DNA Methylation Assay, Methylation, Control